The main objective of this document is to assess the potential impacts on the EPC issuing by the innovative EPC methods developed during the ePANACEA project. For this purpose, we apply diffusion analysis due to policy setting, EPC tools, and market structure. This report follows two streams of work: (1) discussing the impact of renovation measures on energy demand, CO2 emissions, related investments, etc., in different scenarios of the EU-building stock and the pilot countries and (2) analysing the potential evolution of EPC uptake and different methods for issuing EPCs, including the methods developed in the ePANACEA project. Based on the end-user acceptance workshops and analysis performed during the project, it is impossible to directly link the impact of different EPC methods and issuing activities to resulting energy savings. Nevertheless, the joint discussion of these two streams allows for drawing relevant conclusions regarding the future role of expanding EPC methods and applying ePANACEA methods, both of which are presented in this study.